Help Privacy Policy Disclaimer
  Advanced SearchBrowse




Journal Article

Admixture has obscured signals of historical hard sweeps in humans


Rohrlach,  Adam Ben       
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)

(Publisher version), 3MB

Supplementary Material (public)
There is no public supplementary material available

Souilmi, Y., Tobler, R., Johar, A., Williams, M., Grey, S. T., Schmidt, J., et al. (2022). Admixture has obscured signals of historical hard sweeps in humans. Nature Ecology & Evolution, 6, 2003-2015. doi:10.1038/s41559-022-01914-9.

Cite as: https://hdl.handle.net/21.11116/0000-000B-74C1-8
The role of natural selection in shaping biological diversity is an area of
intense interest in modern biology. To date, studies of positive selection
have primarily relied on genomic datasets from contemporary populations,
which are susceptible to confounding factors associated with complex
and often unknown aspects of population history. In particular, admixture
between diverged populations can distort or hide prior selection events
in modern genomes, though this process is not explicitly accounted for in
most selection studies despite its apparent ubiquity in humans and other
species. Through analyses of ancient and modern human genomes, we show
that previously reported Holocene-era admixture has masked more than 50
historic hard sweeps in modern European genomes. Our results imply that
this canonical mode of selection has probably b

een underappreciated in the
evolutionary history of humans and suggest that our current understanding
of the tempo and mode of selection in natural populations may be