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Imaging of cell membraneous and cytoskeletal structures with a scanning tunneling microscope

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Ruppersberg,  Johann Peter
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Hörber,  J. K. Heinrich
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Gerber,  Christoph
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Binnig,  Gert
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Ruppersberg, J. P., Hörber, J. K. H., Gerber, C., & Binnig, G. (1989). Imaging of cell membraneous and cytoskeletal structures with a scanning tunneling microscope. FEBS Letters, 257(2), 460-464. doi:10.1016/0014-5793(89)81596-0.


Cite as: https://hdl.handle.net/21.11116/0000-000B-77F6-A
Abstract
The first observation of unstained cell membraneous structures by a scanning tunneling microscope is reported. An adhesive preparation method was used for imaging human medulloblastoma cells from the cell line TE 671 and oocytes from the clawed toad Xenopus laevis. The images show filaments, stacks of molecules and hilly structures. The possible identify of the filamentous structures is discussed, although the observed structures cannot yet be fully characterized. The work suggests possible future experiments on various biological structures in their natural environment.