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Journal Article

Metabolic Tumor Imaging with Rapidly Signal-Enhanced 1-13C-Pyruvate-d3

MPS-Authors

Hune,  Theresa
Research Group of NMR Signal Enhancement, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

/persons/resource/persons220779

Mamone,  Salvatore
Research Group of NMR Signal Enhancement, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

/persons/resource/persons276728

Schröder,  Henning
Research Group of NMR Signal Enhancement, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Jagtap,  Anil P.
Research Group of NMR Signal Enhancement, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Sternkopf,  Sonja
Research Group of NMR Signal Enhancement, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Stevanato,  Gabriele
Research Group of NMR Signal Enhancement, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

/persons/resource/persons220777

Korchak,  Sergey
Research Group of NMR Signal Enhancement, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

Fokken,  Claudia
Research Group of NMR Signal Enhancement, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Becker,  Dorothea
Department of NMR Based Structural Biology, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Glöggler,  Stefan
Research Group of NMR Signal Enhancement, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Fulltext (public)

ChemPhysChem - 2022.pdf
(Publisher version), 630KB

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Citation

Hune, T., Mamone, S., Schröder, H., Jagtap, A. P., Sternkopf, S., Stevanato, G., et al. (2023). Metabolic Tumor Imaging with Rapidly Signal-Enhanced 1-13C-Pyruvate-d3. ChemPhysChem, 24(2): e202200615. doi:10.1002/cphc.202200615.


Cite as: https://hdl.handle.net/21.11116/0000-000B-7B8C-E
Abstract
The metabolism of malignant cells differs significantly from that of healthy cells and thus, it is possible to perform metabolic imaging to reveal not only the exact location of a tumor, but also intratumoral areas of high metabolic activity. Herein, we demonstrate the feasibility of metabolic tumor imaging using signal-enhanced 1-13C-pyruvate-d3, which is rapidly enhanced via para-hydrogen, and thus, the signal is amplified by several orders of magnitudes in less than a minute. Using as a model, human melanoma xenografts injected with signal-enhanced 1-13C-pyruvate-d3, we show that the conversion of pyruvate into lactate can be monitored along with its kinetics, which could pave the way for rapidly detecting and monitoring changes in tumor metabolism.