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Journal Article

Hippocampal spatio-predictive cognitive maps adaptively guide reward generalization

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Garvert,  Mona       
Department Psychology (Doeller), MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Max Planck Research Group NeuroCode, Max Planck Institute for Human Development, Berlin, Germany;
Max Planck Institute for Biological Cybernetics, Tübingen, Germany;

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Doeller,  Christian F.       
Department Psychology (Doeller), MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits, Kavli Institute, Norwegian University of Science and Technology, Norway;
Institute of Psychology, University of Leipzig, Germany;

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Garvert_2023_Suppl.pdf
(Supplementary material), 336KB

Citation

Garvert, M., Saanum, T., Schulz, E., Schuck, N. W., & Doeller, C. F. (2023). Hippocampal spatio-predictive cognitive maps adaptively guide reward generalization. Nature Neuroscience, 26(4), 615-626. doi:10.1038/s41593-023-01283-x.


Cite as: https://hdl.handle.net/21.11116/0000-000B-7FE5-5
Abstract
The brain forms cognitive maps of relational knowledge, an organizing principle thought to underlie our ability to generalize
and make inferences. However, how can a relevant map be selected in situations where a stimulus is embedded in multiple
relational structures? Here, we find that both spatial and predictive cognitive maps influence generalization in a choice task,
where spatial location determines reward magnitude. Mirroring behavior, the hippocampus not only builds a map of spatial
relationships but also encodes the experienced transition structure. As the task progresses, participants’ choices become
more influenced by spatial relationships, reflected in a strengthening of the spatial and a weakening of the predictive map.
This change is driven by orbitofrontal cortex, which represents the degree to which an outcome is consistent with the spatial
rather than the predictive map and updates hippocampal representations accordingly. Taken together, this demonstrates how
hippocampal cognitive maps are used and updated flexibly for inference.