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Journal Article

Directional cues for retinal axons

MPS-Authors
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Stahl,  B
Department Physical Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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von Boxberg,  Y       
Department Biochemistry, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons283705

Müller,  B       
Department Physical Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Walter,  J
Department Physical Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Schwarz,  U
Department Biochemistry, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons274230

Bonhoeffer,  F
Department Physical Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Citation

Stahl, B., von Boxberg, Y., Müller, B., Walter, J., Schwarz, U., & Bonhoeffer, F. (1990). Directional cues for retinal axons. Cold Spring Harbor Symposia on Quantitative Biology, 55, 351-357. doi:10.1101/sqb.1990.055.01.036.


Cite as: https://hdl.handle.net/21.11116/0000-000B-9DE6-1
Abstract
The elucidation of the mechanisms that govern the development of topographic projections in the central nervous system has been a challenge for neurobiologists for quite some time. Since the pioneering work of Sperry (1956, 1963) on the formation of neural connections in the retinotectal system of amphibia and fish, many speculations have been put forward and dismissed. One of them, which is still a tenable hypothesis, is that the axons are guided to their target site by directional cues expressed on the surface of the target organ given by the graded distribution of substances either diffusible or membrane-bound. As documented in many systems, there are in vivo directional cues for incoming axons at the target surface.