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A common denominator of growth cone guidance and collapse?

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Walter,  J
Department Physical Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Allsopp,  TE
Department Physical Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Bonhoeffer,  F
Department Physical Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Citation

Walter, J., Allsopp, T., & Bonhoeffer, F. (1990). A common denominator of growth cone guidance and collapse? Trends in Neurosciences, 13(11), 447-452. doi:10.1016/0166-2236(90)90097-t.


Cite as: https://hdl.handle.net/21.11116/0000-000B-9E06-D
Abstract
Axonal guidance in the retinotectal system and in spinal nerve segmentation is based on repulsion or inhibition. In both systems the membrane glycoprotein responsible for the guiding activity is capable of inducing growth cone collapse. We discuss two models of axonal guidance that correlate axonal guidance and growth cone collapse. The models are applicable to axon guidance by membrane-associated or diffusible stimuli, and are not based on preferential adhesion of axons to certain substrata.