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Journal Article

Axon guidance by gradients of a target-derived component

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Baier,  H
Department Physical Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Bonhoeffer,  F
Department Physical Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Citation

Baier, H., & Bonhoeffer, F. (1992). Axon guidance by gradients of a target-derived component. Science, 255(5043), 472-475. doi:10.1126/science.1734526.


Cite as: https://hdl.handle.net/21.11116/0000-000B-9E15-C
Abstract
Spatial gradients of axon guiding molecules have long been suspected to provide positional and directional cues for retinal ganglion cell axons growing within the optic tectum. With the identification of a guiding activity from tectal cell membranes, it has become possible to investigate the potential physiological significance of molecular gradients for retinal growth cone behavior in vitro. A subset of retinal growth cones, those from the temporal half, were highly sensitive to small concentration changes of the guiding component. The degree of response was correlated with the strength of the gradient. These findings demonstrate that the neural growth cone can read gradients of surface-associated information.