Novel spiroannulated 3-benzofuranones: Synthesis and inhibition of the human 
peptidyl prolyl cis/trans isomerase Pin1

Braun, M; Hessamian-Alineja, A; Féaux de Lacroix, B; Hernandez Alvarez, B; Fischer, G

doi:10.3390/molecules13040995

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Novel spiroannulated 3-benzofuranones: Synthesis and inhibition of the human peptidyl prolyl cis/trans isomerase Pin1

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Braun, M., Hessamian-Alineja, A., Féaux de Lacroix, B., Hernandez Alvarez, B., & Fischer, G. (2008). Novel spiroannulated 3-benzofuranones: Synthesis and inhibition of the human peptidyl prolyl cis/trans isomerase Pin1. Molecules, 13(4), 995-1003. doi:10.3390/molecules13040995.

Cite as: https://hdl.handle.net/21.11116/0000-000B-A768-4

Abstract

The novel 3H-spiro[1-benzofuran-2-cyclopentan]-3-one skeleton has been made accessible by different routes. One- and two-step protocols lead to tricyclic and tetracyclic benzofuranones 2 and 3, respectively. A four-step synthesis to spirocompound 4 is described. The novel spirocyclic benzofuranones display modest to no inhibition of the human peptidyl prolyl cis/trans isomerase Pin1.