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Journal Article

Modulation of EphA receptor function by coexpressed ephrinA ligands on retinal ganglion cell axons

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Hornberger,  MR
Department Physical Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons283716

Dütting,  D
Department Physical Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons284125

Ciossek,  T
Department Physical Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons284104

Handwerker,  C
Department Physical Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons38957

Lang,  S
Department Physical Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons283378

Weth,  F       
Department Physical Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons283768

Huf,  J
Department Physical Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons284123

Weßel,  R
Department Physical Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Citation

Hornberger, M., Dütting, D., Ciossek, T., Yamada, T., Handwerker, C., Lang, S., et al. (1999). Modulation of EphA receptor function by coexpressed ephrinA ligands on retinal ganglion cell axons. Neuron, 22(4), 731-742. doi:10.1016/s0896-6273(00)80732-1.


Cite as: https://hdl.handle.net/21.11116/0000-000B-B24B-8
Abstract
The Eph family is thought to exert its function through the complementary expression of receptors and ligands. Here, we show that EphA receptors colocalize on retinal ganglion cell (RGC) axons with EphA ligands, which are expressed in a high-nasal-to-low-temporal pattern. In the stripe assay, only temporal axons are normally sensitive for repellent axon guidance cues of the caudal tectum. However, overexpression of ephrinA ligands on temporal axons abolishes this sensitivity, whereas treatment with PI-PLC both removes ephrinA ligands from retinal axons and induces a striped outgrowth of formerly insensitive nasal axons. In vivo, retinal overexpression of ephrinA2 leads to topographic targeting errors of temporal axons. These data suggest that differential ligand expression on retinal axons is a major determinant of topographic targeting in the retinotectal projection.