English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Limited microsynteny between the genomes of Pristionchus pacificus and Caenorhabditis elegans

MPS-Authors
/persons/resource/persons282479

Lee,  K-Z
Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons278455

Eizinger,  A
Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons282446

Nandakumar,  R
Genome Center, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons78680

Schuster,  SC
Genome Center, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons271084

Sommer,  RJ       
Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Lee, K.-Z., Eizinger, A., Nandakumar, R., Schuster, S., & Sommer, R. (2003). Limited microsynteny between the genomes of Pristionchus pacificus and Caenorhabditis elegans. Nucleic Acids Research (London), 31(10), 2553-2560. doi:10.1093/nar/gkg359.


Cite as: https://hdl.handle.net/21.11116/0000-000B-B257-A
Abstract
Nematodes are an attractive group of organisms for studying the evolution of developmental processes. Pristionchus pacificus was established as a satellite organism for comparing vulva development and other processes to Caenorhabditis elegans. The generation of a genetic linkage map of P.pacificus has provided a first insight into the structure and organization of the genome of this species. Pristionchus pacificus and C.elegans are separated from one another by >100 000 000 years such that the structure of the genomes of these two nematodes might differ substantially. To evaluate the amount of synteny between the two genomes, we have obtained 126 kb of continuous genomic sequence of P.pacificus, flanking the developmental patterning gene pal-1. Of the 20 predicted open reading frames in this interval, 11 have C.elegans orthologs. Ten of these 11 orthologs are located on C.elegans chromosome III, indicating the existence of synteny. However, most of these genes are distributed over a 12 Mb interval of the C.elegans genome and only three pairs of genes show microsynteny. Thus, intrachromosomal rearrange ments occur frequently in nematodes, limiting the likelihood of identifying orthologous genes of P.pacificus and C.elegans based on positional information within the two genomes.