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Journal Article

Paternal nutritional programming of lipid metabolism is propagated through sperm and seminal plasma

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Chiarugi,  Davide
Methods and Development Group Computing and Databases Services, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Citation

Furse, S., Watkins, A. J., Williams, H. E. L., Snowden, S. G., Chiarugi, D., & Koulman, A. (2022). Paternal nutritional programming of lipid metabolism is propagated through sperm and seminal plasma. Metabolomics, 18(2): 13. doi:10.1007/s11306-022-01869-9.


Cite as: https://hdl.handle.net/21.11116/0000-000B-F2B5-7
Abstract
Background: The paternal diet affects lipid metabolism in offspring for at least two generations through nutritional programming. However, we do not know how this is propagated to the offspring.

Objectives: We tested the hypothesis that the changes in lipid metabolism that are driven by paternal diet are propagated through spermatozoa and not seminal plasma.

Methods: We applied an updated, purpose-built computational network analysis tool to characterise control of lipid metabolism systemically (Lipid Traffic Analysis v2.3) on a known mouse model of paternal nutritional programming.

Results: The analysis showed that the two possible routes for programming effects, the sperm (genes) and seminal plasma (influence on the uterine environment), both have a distinct effect on the offspring's lipid metabolism. Further, the programming effects in offspring suggest that changes in lipid distribution are more important than alterations in lipid biosynthesis.

Conclusions: These results show how the uterine environment and genes both affect lipid metabolism in offspring, enhancing our understanding of the link between parental diet and metabolism in offspring.