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Conference Paper

Differentiable Optics for Wavefront Sensing in Two-photon Fluorescence Microscopy

MPS-Authors
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Vishniakou,  Ivan
Max Planck Research Group Neural Circuits, Max Planck Institute for Neurobiology of Behavior – caesar, Max Planck Society;

/persons/resource/persons188171

Seelig,  Johannes D.       
Max Planck Research Group Neural Circuits, Max Planck Institute for Neurobiology of Behavior – caesar, Max Planck Society;

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https://opg.optica.org/abstract.cfm?uri=AOA-2022-OW3G.5
(Abstract)

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Citation

Vishniakou, I., & Seelig, J. D. (2022). Differentiable Optics for Wavefront Sensing in Two-photon Fluorescence Microscopy. In Adaptive Optics and Applications 2022. doi:10.1364/AOA.2022.OW3G.5.


Cite as: https://hdl.handle.net/21.11116/0000-000B-F5A1-A
Abstract
We develop a differentiable physics approach for adaptive optics in fluorescence microscopy. Image formation in the microscope is described using a vectorial Debye-Wolf model. Unknown sample aberrations are found and corrected by adjusting model parameters using gradient-based optimisation and only a small number of aberrated images.