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Identification of a putative cell adhesion domain of uvomorulin

MPG-Autoren
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Vestweber,  D       
Kemler Group, Friedrich Miescher Laboratory, Max Planck Society;

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Kemler,  R
Kemler Group, Friedrich Miescher Laboratory, Max Planck Society;

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Zitation

Vestweber, D., & Kemler, R. (1985). Identification of a putative cell adhesion domain of uvomorulin. EMBO Journal, 4(13A), 3393-3398. doi:10.1002/j.1460-2075.1985.tb04095.x.


Zitierlink: https://hdl.handle.net/21.11116/0000-000C-0595-6
Zusammenfassung
A rat monoclonal antibody (DECMA-1) selected against the murine cell adhesion molecule uvomorulin blocks both the aggregation of mouse embryonal carcinoma cells and the compaction of pre-implantation embryos. However, decompacted embryos eventually become recompacted in the presence of DECMA-1 and form blastocysts composed of both trophectoderm and inner cell mass. DECMA-1 also disrupts confluent monolayers of Madin-Darby canine kidney (MDCK) epithelial cells. DECMA-1 recognizes uvomorulin in extracts from mouse and dog tissues. Protease digestion of mouse and dog uvomorulin generated core fragments including one of 26 kd which reacted with DECMA-1. The same 26-kd fragment is recognized by anti-uvomorulin monoclonal antibodies which have been obtained from other laboratories and which dissociate MDCK cell monolayers and block the formation of the epithelial occluding barrier. This 26-kd fragment therefore seems to be involved in the adhesive function of uvomorulin.