A conserved family of nuclear proteins containing structural elements of the 
finger protein encoded by Krüppel, a Drosophila segmentation gene

Schuh, R; Aicher, W; Gaul, U; Côté, S; Preiss, A; Maier, D; Seifert, E; Nauber, U; Schröder, C; Kemler, R; Jäckle, H

doi:10.1016/0092-8674(86)90817-2

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

A conserved family of nuclear proteins containing structural elements of the finger protein encoded by Krüppel, a Drosophila segmentation gene

MPS-Authors

/persons/resource/persons191147

Kemler, R
Kemler Group, Friedrich Miescher Laboratory, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Schuh, R., Aicher, W., Gaul, U., Côté, S., Preiss, A., Maier, D., et al. (1986). A conserved family of nuclear proteins containing structural elements of the finger protein encoded by Krüppel, a Drosophila segmentation gene. Cell, 47(6), 1025-1032. doi:10.1016/0092-8674(86)90817-2.

Cite as: https://hdl.handle.net/21.11116/0000-000C-07C5-E

Abstract

Krüppel (Kr), a segmentation gene of Drosophila, encodes a protein sharing structural features of the DNA-binding "finger motif" of TFIIIA, a Xenopus transcription factor. Low-stringency hybridization of the Kr finger coding sequence revealed multiple copies of homologous DNA sequences in the genomes of Drosophila and other eukaryotes. Molecular analysis of one Kr-homologous DNA clone identified a developmentally regulated gene. Its product, a finger protein, relates to Kr by the invariant positioning of crucial amino acid residues within the finger repeats and by a stretch of seven amino acids connecting the finger loops, the "H/C link." This H/C link is conserved in several nuclear and chromosome-associated proteins of Drosophila and other eukaryotic organisms including mammals. Our results demonstrate a new subfamily of evolutionarily conserved nuclear and possibly DNA-binding proteins that again relate to a Drosophila segmentation gene as in the case of the homeo domain.