Decarboxylative sulfoximination of benzoic acids enabled by photoinduced 
ligand-to-copper charge transfer

Xu, Peng; Su, Wanqi; Ritter, Tobias

doi:10.1039/D2SC05442F

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Decarboxylative sulfoximination of benzoic acids enabled by photoinduced ligand-to-copper charge transfer

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Xu, Peng
Research Department Ritter, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Su, Wanqi
Research Department Ritter, Max-Planck-Institut für Kohlenforschung, Max Planck Society;
Institute of Organic Chemistry, RWTH Aachen University;

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Ritter, Tobias
Research Department Ritter, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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引用

Xu, P., Su, W., & Ritter, T. (2022). Decarboxylative sulfoximination of benzoic acids enabled by photoinduced ligand-to-copper charge transfer. Chemical Science, 13(45), 13611-13616. doi:10.1039/D2SC05442F.

引用: https://hdl.handle.net/21.11116/0000-000C-1DFD-8

要旨

Sulfoximines are synthetically important scaffolds and serve important roles in drug discovery. Currently, there is no solution to decarboxylative sulfoximination of benzoic acids; although thoroughly investigated, limited substrate scope and harsh reaction conditions still hold back traditional thermal aromatic decarboxylative functionalization. Herein, we realize the first decarboxylative sulfoximination of benzoic acids via photo-induced ligand to copper charge transfer (copper-LMCT)-enabled decarboxylative carbometalation. The transformation proceeds under mild reaction conditions, has a broad substrate scope, and can be applied to late-stage functionalization of complex small molecules.