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From bioinformatics to structure: insight into the mechanism of transmembrane signal transduction

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Lupas,  A       
Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society;

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Lupas, A. (2008). From bioinformatics to structure: insight into the mechanism of transmembrane signal transduction. In Basel Computational Biology Conference 2008: "Computational Structural Biology".


Cite as: https://hdl.handle.net/21.11116/0000-000C-3407-2
Abstract
The structural mechanism by which receptors transduce chemical signals across membranes is still largely unknown. The planarity of the membrane limits the types of motion that transmembrane helices can undergo during signal transduction to four: translation in the plane of the membrane (association/dissociation), translation perpendicular to the membrane (piston motion), rotation along an axis parallel to the membrane (pivot motion), and rotation along an axis perpendicular to the membrane. We are using the HAMP domain as a model system to investigate this problem. HAMP is of particular interest for understanding signal propagation across the membrane because it is continuous with the last membrane-spanning helix of a wide range of sensory modules. Through a combination of bioinformatics, biochemistry, and structural biology (crystallography and NMR), we have developed a detailed model for the propagation of the signal by helix rotation along an axis perpendicular to the membrane.