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Journal Article

Autoantibodies against NMDAR subunit NR1 disappear from blood upon anesthesia

MPS-Authors
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Wilke,  Justus B. H.
Research Group of Clinical Neuroscience, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Hindermann,  Martin
Research Group of Clinical Neuroscience, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Ehrenreich,  Hannelore
Research Group of Clinical Neuroscience, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Citation

Teller, J., Jung, C., Wilke, J. B. H., Schimmelpfennig, S.-D., Hindermann, M., Hinken, L., et al. (2022). Autoantibodies against NMDAR subunit NR1 disappear from blood upon anesthesia. Brain, Behavior, & Immunity - Health, 24: 100494. doi:10.1016/j.bbih.2022.100494.


Cite as: https://hdl.handle.net/21.11116/0000-000C-34D9-5
Abstract
Anesthetics penetrate the blood-brain-barrier (BBB) and - as confirmed preclinically – transiently disrupt it. An analogous consequence in humans has remained unproven. In mice, we previously reported that upon BBB dysfunction, the brain acts as ‘immunoprecipitator’ of autoantibodies against N-methyl-D-aspartate-receptor subunit-NR1 (NMDAR1-AB). We thus hypothesized that during human anesthesia, pre-existing NMDAR1-AB will specifically bind to brain. Screening of N = 270 subjects undergoing general anesthesia during cardiac surgery for serum NMDAR1-AB revealed N = 25 NMDAR1-AB seropositives. Only N = 14 remained positive post-surgery. No changes in albumin, thyroglobulin or CRP were associated with reduction of serum NMDAR1-AB. Thus, upon anesthesia, BBB opening likely occurs also in humans.