English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Review Article

Metabolic Signatures from Genebank Collections: An Underexploited Resource for Human Health?

MPS-Authors
/persons/resource/persons104918

Alseekh,  S.
The Genetics of Crop Metabolism, Department Gutjahr, Max Planck Institute of Molecular Plant Physiology, Max Planck Society;

/persons/resource/persons97147

Fernie,  A. R.
Central Metabolism, Department Gutjahr, Max Planck Institute of Molecular Plant Physiology, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Sreenivasulu, N., Alseekh, S., Tiozon, R. N., Graner, A., Martin, C., & Fernie, A. R. (2023). Metabolic Signatures from Genebank Collections: An Underexploited Resource for Human Health? Annual Review of Food Science and Technology, 14, 183-202. doi:10.1146/annurev-food-060822-113022.


Cite as: https://hdl.handle.net/21.11116/0000-000C-359E-7
Abstract
Despite the almost universal acceptance of the phrase ?you are what you eat,? investment in understanding diet-based nutrition to address human health has been dwarfed compared to that for medicine-based interventions. Moreover, traditional breeding has focused on yield to the detriment of nutritional quality, meaning that although caloric content has remained high, the incidence of nutritional deficiencies and accompanying diseases (so-called hidden hunger) has risen dramatically. We review how genome sequencing coupled with metabolomics can facilitate the screening of genebank collections in the search for superior alleles related to the nutritional quality of crops. We argue that the first examples are very promising, suggesting that this approach could benefit broader ranges of crops and compounds with known relevance for human health. We argue that this represents an approach complementary to metabolic engineering by transgenesis or gene editing that could be used to reverse some of the losses incurred through a recent focus on breeding for yield, although we caution that ensuring such approaches are not (re)introducing antinutrients is also necessary. Furthermore, deploying effective postharvest processing technologies to increase the density of nutrients in the food matrix and improve palatability remains an attractive alternative. Expected final online publication date for the Annual Review of Food Science and Technology, Volume 14 is March 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.