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Journal Article

Tripartite extended amygdala-basal ganglia CRH circuit drives locomotor activation and avoidance behavior

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Chang,  Simon
RG Molecular Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

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Jakovcevski,  Mira
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

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Di Giaimo,  Rossella
Max Planck Research Group Developmental Neurobiology (Silvia Cappello), Max Planck Institute of Psychiatry, Max Planck Society;

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Gagliardi,  Miriam
RG Genomics of Complex Diseases, Max Planck Institute of Psychiatry, Max Planck Society;

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Menegaz,  Danusa
Max Planck Institute of Psychiatry, Max Planck Society;

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Ziller,  Michael
RG Genomics of Complex Diseases, Max Planck Institute of Psychiatry, Max Planck Society;

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Eder,  Matthias
Max Planck Institute of Psychiatry, Max Planck Society;

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Deussing,  Jan M.
RG Molecular Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

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Citation

Chang, S., Fermani, F., Lao, C.-L., Huang, L., Jakovcevski, M., Di Giaimo, R., et al. (2022). Tripartite extended amygdala-basal ganglia CRH circuit drives locomotor activation and avoidance behavior. SCIENCE ADVANCES, 8(46). doi:10.1126/sciadv.abo1023.


Cite as: https://hdl.handle.net/21.11116/0000-000C-7BF9-2
Abstract
An adaptive stress response involves various mediators and circuits orchestrating a complex interplay of physiological, emotional, and behavioral adjustments. We identified a population of corticotropin- releasing hormone (CRH) neurons in the lateral part of the interstitial nucleus of the anterior commissure (IPACL), a subdivision of the extended amygdala, which exclusively innervate the substantia nigra ( SN). Specific stimulation of this circuit elicits hyperactivation of the hypothalamic-pituitary-adrenal axis, locomotor activation, and avoidance behavior contingent on CRH receptor type 1 (CRHR1) located at axon terminals in the SN, which originate from external globus pallidus (GPe) neurons. The neuronal activity prompting the observed behavior is shaped by IPACLCRH and GPeCRHR1 neurons coalescing in the SN. These results delineate a previously unidentified tripartite CRH circuit functionally connecting extended amygdala and basal ganglia nuclei to drive locomotor activation and avoidance behavior.