Tripartite extended amygdala-basal ganglia CRH circuit drives locomotor 
activation and avoidance behavior

Chang, Simon; Fermani, Federica; Lao, Chu-Lan; Huang, Lianyun; Jakovcevski, Mira; Di Giaimo, Rossella; Gagliardi, Miriam; Menegaz, Danusa; Hennrich, Alexandru Adrian; Ziller, Michael; Eder, Matthias; Klein, Rudiger; Cai, Na; Deussing, Jan M.

doi:10.1126/sciadv.abo1023

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Tripartite extended amygdala-basal ganglia CRH circuit drives locomotor activation and avoidance behavior

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Chang, Simon
RG Molecular Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

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Jakovcevski, Mira
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons222059

Di Giaimo, Rossella
Max Planck Research Group Developmental Neurobiology (Silvia Cappello), Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons237993

Gagliardi, Miriam
RG Genomics of Complex Diseases, Max Planck Institute of Psychiatry, Max Planck Society;

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Menegaz, Danusa
Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons203557

Ziller, Michael
RG Genomics of Complex Diseases, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80315

Eder, Matthias
Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80301

Deussing, Jan M.
RG Molecular Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

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引用

Chang, S., Fermani, F., Lao, C.-L., Huang, L., Jakovcevski, M., Di Giaimo, R., Gagliardi, M., Menegaz, D., Hennrich, A. A., Ziller, M., Eder, M., Klein, R., Cai, N., & Deussing, J. M. (2022). Tripartite extended amygdala-basal ganglia CRH circuit drives locomotor activation and avoidance behavior. SCIENCE ADVANCES, 8(46). doi:10.1126/sciadv.abo1023.

引用: https://hdl.handle.net/21.11116/0000-000C-7BF9-2

要旨

An adaptive stress response involves various mediators and circuits orchestrating a complex interplay of physiological, emotional, and behavioral adjustments. We identified a population of corticotropin- releasing hormone (CRH) neurons in the lateral part of the interstitial nucleus of the anterior commissure (IPACL), a subdivision of the extended amygdala, which exclusively innervate the substantia nigra ( SN). Specific stimulation of this circuit elicits hyperactivation of the hypothalamic-pituitary-adrenal axis, locomotor activation, and avoidance behavior contingent on CRH receptor type 1 (CRHR1) located at axon terminals in the SN, which originate from external globus pallidus (GPe) neurons. The neuronal activity prompting the observed behavior is shaped by IPACLCRH and GPeCRHR1 neurons coalescing in the SN. These results delineate a previously unidentified tripartite CRH circuit functionally connecting extended amygdala and basal ganglia nuclei to drive locomotor activation and avoidance behavior.