Function of DNA Polymerase III in DNA Replication

Nüsslein, V; Otto, B; Bonhoeffer, F; Schaller, H

doi:10.1038/newbio234285a0

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Function of DNA Polymerase III in DNA Replication

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Nüsslein, V
Bonhoeffer Group, Friedrich Miescher Laboratory, Max Planck Society;

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Otto, B
Bonhoeffer Group, Friedrich Miescher Laboratory, Max Planck Society;

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Bonhoeffer, F
Bonhoeffer Group, Friedrich Miescher Laboratory, Max Planck Society;

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Schaller, H
Bonhoeffer Group, Friedrich Miescher Laboratory, Max Planck Society;

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Citation

Nüsslein, V., Otto, B., Bonhoeffer, F., & Schaller, H. (1971). Function of DNA Polymerase III in DNA Replication. Nature New Biology, 234(52), 285-286. doi:10.1038/newbio234285a0.

Cite as: https://hdl.handle.net/21.11116/0000-000C-456C-E

Abstract

Recently an in vitro system for DNA replication has been described. This system could be divided into two fractions (A and B) both of which are necessary for proper DNA replication1. Fraction A, the “soluble” fraction, contains those proteins which do not tightly bind to membranes or native DNA. Fraction B, the “insoluble” fraction, consists of DNA and membranous structures and proteins which are bound to either of them. It was shown that the soluble fraction contains at least one component which is needed at about in vivo concentration1. Studies of one such component are described in the following.