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Synthetische Zipper für die Biosynthese neuer Naturstoffderivate

MPS-Authors
/persons/resource/persons268929

Abbood,  Nadya
Natural Product Function and Engineering, Department of Natural Products in Organismic Interactions, Max Planck Institute for Terrestrial Microbiology, Max Planck Society;
Goethe-Universität Frankfurt am Main, External Organizations;

/persons/resource/persons267280

Bozhüyük,  Kenan A. J.
Natural Product Function and Engineering, Department of Natural Products in Organismic Interactions, Max Planck Institute for Terrestrial Microbiology, Max Planck Society;
Goethe-Universität Frankfurt am Main, External Organizations;

/persons/resource/persons256033

Bode,  Helge B.       
Molecular Biotechnology, Department of Biosciences, Goethe University Frankfurt, Frankfurt, Germany, External Organizations;
Chemical Biology, Department of Chemistry, Philipps University Marburg, Marburg, Germany;
Natural Product Function and Engineering, Department of Natural Products in Organismic Interactions, Max Planck Institute for Terrestrial Microbiology, Max Planck Society;

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https://doi.org/10.1007/s12268-022-1785-7
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Citation

Abbood, N., Bozhüyük, K. A. J., & Bode, H. B. (2022). Synthetische Zipper für die Biosynthese neuer Naturstoffderivate. Biospektrum, 28(4), 446-449. doi:10.1007/s12268-022-1785-7.


Cite as: https://hdl.handle.net/21.11116/0000-000C-722A-5
Abstract
A rich source of new therapeutics are natural products derived from modular non-ribosomal peptide synthetases (e. g. penicillins, daptomycin). Yet, efficient bioengineering of these often gigantic megaenzymes to generate natural product analogs is a major challenge. Using synthetic zippers, we have established a co-expression strategy that not only simplifies bioengineering, but rapidly increases the biocombinatorial potential and throughput of reprogrammed NRPS.