Design centering enables robustness screening of pattern formation models.

Solomatina, Anastasia; Cezanne, Alice; Kalaidzidis, Yannis; Zerial, Marino; Sbalzarini, Ivo F.

doi:10.1093/bioinformatics/btac480

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Design centering enables robustness screening of pattern formation models.

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Solomatina, Anastasia
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Cezanne, Alice
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Kalaidzidis, Yannis
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Zerial, Marino
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Sbalzarini, Ivo F.
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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https://publications.mpi-cbg.de/Solomatina_2022_8447.pdf
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引用

Solomatina, A., Cezanne, A., Kalaidzidis, Y., Zerial, M., & Sbalzarini, I. F. (2022). Design centering enables robustness screening of pattern formation models. Bioinformatics (Oxford, England), 38(Suppl 2):. doi:10.1093/bioinformatics/btac480.

引用: https://hdl.handle.net/21.11116/0000-000C-7479-A

要旨

Access to unprecedented amounts of quantitative biological data allows us to build and test biochemically accurate reaction-diffusion models of intracellular processes. However, any increase in model complexity increases the number of unknown parameters and, thus, the computational cost of model analysis. To efficiently characterize the behavior and robustness of models with many unknown parameters remains, therefore, a key challenge in systems biology.