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Journal Article

Oocytes and embryos of Xenopus laevis express two different isoforms of germ cell nuclear factor (GCNF, NR6A1)

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Schohl,  A
Department Cell Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Barretto,  G
Department Cell Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Joos,  TO       
Department Cell Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Dreyer,  C
Department Cell Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Citation

Schohl, A., Barretto, G., Joos, T., & Dreyer, C. (2002). Oocytes and embryos of Xenopus laevis express two different isoforms of germ cell nuclear factor (GCNF, NR6A1). Mechanisms of Development, 118(1-2), 261-264. doi:10.1016/s0925-4773(02)00281-2.


Cite as: https://hdl.handle.net/21.11116/0000-000C-7DC8-7
Abstract
The germ cell nuclear factor (GCNF) is a nuclear orphan receptor and a putative regulator of the pluripotent state of cells. Although it was first described in mouse germ cells, GCNF is also expressed in mouse and Xenopus embryos. By means of 5'RACE we have identified a novel isoform of Xenopus laevis GCNF that is predominantly expressed in germ cells, whereas both the oocyte and embryonic forms are expressed during Xenopus embryogenesis. EST database search revealed that the homologues of both isoforms are also transcribed in Xenopus tropicalis.