English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Automated glycan assembly of mycobacterial hexaarabinofuranoside and docosasaccharide arabinan (Araf23) motifs found on mycobacterium tuberculosis

MPS-Authors
/persons/resource/persons260857

Sabbavarapu,  Narayana Murthy       
Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons121849

Seeberger,  Peter H.       
Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)

Article.pdf
(Publisher version), 3MB

Supplementary Material (public)
There is no public supplementary material available
Citation

Sabbavarapu, N. M., & Seeberger, P. H. (2023). Automated glycan assembly of mycobacterial hexaarabinofuranoside and docosasaccharide arabinan (Araf23) motifs found on mycobacterium tuberculosis. Chemistry – A European Journal, 29(23): e202300032. doi:10.1002/chem.202300032.


Cite as: https://hdl.handle.net/21.11116/0000-000C-90A1-A
Abstract
Mycobacteria are covered in a thick layer of different polysaccharides that helps to avert the innate immune response. Lipoarabinomannan (LAM) and arabinogalactan (AG) are ubiquitously contained in these envelopes and rapid access to defined oligo- and polysaccharides is essential to elucidate their structural and biological roles. Arabinofuranose (Araf)residues in LAM and AG are connected either via α-1,2-trans linkages that are synthetically straightforward to install or the more challenging β-(1,2-cis) linkages. Here, we demonstrate that automated glycan assembly (AGA) can be used to quickly prepare 1,2-cis-β-Araf as illustrated by the assembly of a highly branched arabinan hexasaccharide and a docosasaccharide arabinan (Araf23) motif