Physical determinants of cell organization in soft media

Schwarz, US; Bischofs, I. B.

doi:10.1016/j.medengphy.2005.04.007

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Physical determinants of cell organization in soft media

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Bischofs, I. B.
BioQuant Center of the University of Heidelberg;
Theorie & Bio-Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Schwarz, U., & Bischofs, I. B. (2005). Physical determinants of cell organization in soft media. MEDICAL ENGINEERING & PHYSICS, 27(9), 763-772. doi:10.1016/j.medengphy.2005.04.007.

Cite as: https://hdl.handle.net/21.11116/0000-000C-91CD-9

Abstract

Cell adhesion is an integral part of many physiological processes in tissues, including development, tissue maintenance, angiogenesis, and wound healing. Recent advances in materials science (including microcontact printing, soft lithography, microfluidics, and nanotechnology) have led to strongly improved control of extracellular ligand distribution and of the properties of the micromechanical environment. As a result, the investigation of cellular response to the physical properties of adhesive surfaces has become a very active area of research. Sophisticated use of elastic substrates has revealed that cell organization in soft media is determined by active mechanosensing at cell-matrix adhesions. In order to determine the underlying mechanisms, quantification and biophysical modelling are essential. In tissue engineering, theory might help to design new environments for cells. (c) 2005 IPEM. Published by Elsevier Ltd. All rights reserved.