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Journal Article

Immunoglobulin heavy-chain class switching in a pre-B cell line is accompanied by DNA rearrangement

MPS-Authors
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Burrows,  PD
Wabl Group, Friedrich Miescher Laboratory, Max Planck Society;

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Beck-Engeser,  GB
Wabl Group, Friedrich Miescher Laboratory, Max Planck Society;

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Wabl,  M
Wabl Group, Friedrich Miescher Laboratory, Max Planck Society;

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Citation

Burrows, P., Beck-Engeser, G., & Wabl, M. (1983). Immunoglobulin heavy-chain class switching in a pre-B cell line is accompanied by DNA rearrangement. Nature, 306(5940), 243-246. doi:10.1038/306243a0.


Cite as: https://hdl.handle.net/21.11116/0000-000C-A003-B
Abstract
Switching of an Abelson virus-transformed mouse lymphoid cell line from immunoglobulin μ to γ2b heavy-chain synthesis in vitro is accompanied by loss of DNA sequences between the JH and Cγ2b gene segments, and thus cannot be explained by differential RNA processing. The light-chain loci of both μ- and γ2b-producing cell clones are in the embryonic configuration, which indicates that class switching can occur in pre-B cells.