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Journal Article

Allelic exclusion of immunoglobulin expression is not caused by somatic segregation

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Wabl,  MR
Wabl Group, Friedrich Miescher Laboratory, Max Planck Society;

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Tenkhoff,  M
Wabl Group, Friedrich Miescher Laboratory, Max Planck Society;

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Citation

Wabl, M., & Tenkhoff, M. (1982). Allelic exclusion of immunoglobulin expression is not caused by somatic segregation. Proceedings of the National Academy of Sciences of the United States of America, 79(2), 606-607. doi:10.1073/pnas.79.2.606.


Cite as: https://hdl.handle.net/21.11116/0000-000C-A033-5
Abstract
We have investigated the karyotype of immunoglobulin-producing cells in heterozygous animals. Using a karyotypic marker for one homolog of a chromosome carrying immunoglobulin genes, we established that immunoglobulin-producing cells are heterozygous with respect to this chromosome. Therefore, allelic exclusion of immunoglobulin expression cannot be caused by somatic chromosome segregation.