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Journal Article

A Mott cell hybridoma

MPS-Authors
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Weiss,  S
Wabl Group, Friedrich Miescher Laboratory, Max Planck Society;

/persons/resource/persons287051

Burrows,  PD
Wabl Group, Friedrich Miescher Laboratory, Max Planck Society;

/persons/resource/persons287065

Meyer,  J
Wabl Group, Friedrich Miescher Laboratory, Max Planck Society;

/persons/resource/persons287034

Wabl,  MR
Wabl Group, Friedrich Miescher Laboratory, Max Planck Society;

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Citation

Weiss, S., Burrows, P., Meyer, J., & Wabl, M. (1984). A Mott cell hybridoma. European Journal of Immunology, 14(8), 744-748. doi:10.1002/eji.1830140814.


Cite as: https://hdl.handle.net/21.11116/0000-000C-A047-F
Abstract
A hybridoma is described that exhibits all the characteristic features of Mott cells. It has spherules (Russell bodies) in the cytoplasm made up of dilated rough endoplasmatic reticulum and containing condensed immunoglobulin (lambda 1 light chains). Some of the cells appear to be very fragile, and free spherules are often found on cell smears. Cells with the Mott cell characteristics are still able to divide, but they do not secrete immunoglobulin. Hybridomas of this kind should be useful for determining the place of the Mott cell within the scheme of B cell differentiation.