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Immunoglobulin heavy chain toxicity in plasma cells is neutralized by fusion to pre-B cells

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Haas,  IG
Wabl Group, Friedrich Miescher Laboratory, Max Planck Society;

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Wabl,  MR
Wabl Group, Friedrich Miescher Laboratory, Max Planck Society;

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Citation

Haas, I., & Wabl, M. (1984). Immunoglobulin heavy chain toxicity in plasma cells is neutralized by fusion to pre-B cells. Proceedings of the National Academy of Sciences of the United States of America, 81(22), 7185-7188. doi:10.1073/pnas.81.22.7185.


Cite as: https://hdl.handle.net/21.11116/0000-000C-A049-D
Abstract
A plasma cell hybridoma frequently loses its immunoglobulin heavy (H) chain spontaneously but rarely is production of its light (L) chain lost. Upon fusion to a pre-B-cell hybridoma that produces no Ig chain, the L chain is frequently lost. In cells without the L chain the H chain, which is derived from the plasma cell, is not chemically modified. Our results indicate that, in pre-B cells, but not in plasma cells, there must be a mechanism that neutralizes the toxic effect of free H chain.