Transforming growth factor-beta inhibits endothelial cell proliferation

Fràter-Schröder, M; Müller, G; Birchmeier, W; Böhlen, P

doi:10.1016/0006-291x(86)91209-x

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Transforming growth factor-beta inhibits endothelial cell proliferation

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Müller, G
Birchmeier Group, Friedrich Miescher Laboratory, Max Planck Society;

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Birchmeier, W
Birchmeier Group, Friedrich Miescher Laboratory, Max Planck Society;

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Citation

Fràter-Schröder, M., Müller, G., Birchmeier, W., & Böhlen, P. (1986). Transforming growth factor-beta inhibits endothelial cell proliferation. Biochemical and Biophysical Research Communications, 137(1), 295-302. doi:10.1016/0006-291x(86)91209-x.

Cite as: https://hdl.handle.net/21.11116/0000-000C-A0C5-0

Abstract

Transforming growth factor-beta (TGF-beta) is an inhibitor of the proliferation of bovine aortic endothelial cells in culture. Basal cell growth in serum-containing medium and cell proliferation stimulated by fibroblast growth factor (FGF) are inhibited by TGF-beta in a dose-dependent manner. Half-maximal inhibition occurs at an inhibitor concentration of 0.5-1.0 ng/ml. TGF-beta does not appear to be cytotoxic and cells treated with the inhibitor grow normally after removal of TGF-beta. High concentrations of FGF are ineffective in overcoming TGF-beta-induced inhibition of cell proliferation, suggesting that antagonism of growth factor-induced cell proliferation by TGF-beta is of a noncompetitive nature.