アイテム詳細

要旨

The recent publication of several whole genome sequences and genome-wide SNP data provide sufficiently large data sets for the genome-wide detection of natural selection in Arabidopsis thaliana. Demographic effects and population structure affect both, the effectivity of selection and our ability to detect the signature of selection. We analyzed the genome-wide data sets from A. thaliana and detected some species-wide and population specific signals of positive as well as purifying selection. Some genomic regions in A. thaliana show a strong haplotype structure, low diversity and/or high differentiation between populations, which are genetic signatures of selection. We identified candidate genes for positive selection which may be involved in pathogen defense and response to climatic conditions. Additionally, we show a strong correlation between the effectivity of purifying selection and the size of a population as well as the influence of ecological constraints in plants.