English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Major role for neuronal death during brain development: refinement of topographical connections

MPS-Authors
/persons/resource/persons283774

Thanos,  S
Department Physical Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Catsicas, S., Thanos, S., & Clarke, P. (1987). Major role for neuronal death during brain development: refinement of topographical connections. Proceedings of the National Academy of Sciences of the United States of America, 84(22), 8165-8168. doi:10.1073/pnas.84.22.8165.


Cite as: https://hdl.handle.net/21.11116/0000-000C-A9DC-E
Abstract
The precision of the topographic projection from the isthmo-optic nucleus (ION) to the retina has been examined in chicken embryos and chicks by the retrograde transport of a fluorescent carbocyanine dye from restricted retinal sites. At all ages, the labeled neurons are most numerous in the topographically appropriate part of the ION, but in younger embryos up to 49% of them are found outside this region. The distribution of these "aberrantly" projecting neurons is variable, but they generally occur throughout the entire ION. They all die during the ION's period of neuronal death, accounting for most of the 60% cell loss that then occurs. We therefore suggest that a major role of neuronal death during brain development is to reduce the imprecision of neuronal connections.