CtHtrA: the lynchpin of the chlamydial surface and a promising therapeutic 
target

Marsh, JW; Ong, VA; Lott, WB; Timms, P; Tyndall, JDA; Huston, WM

doi:10.2217/fmb-2017-0017

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CtHtrA: the lynchpin of the chlamydial surface and a promising therapeutic target

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Marsh, J., Ong, V., Lott, W., Timms, P., Tyndall, J., & Huston, W. (2017). CtHtrA: the lynchpin of the chlamydial surface and a promising therapeutic target. Future Microbiology, 12(9), 817-829. doi:10.2217/fmb-2017-0017.

Cite as: https://hdl.handle.net/21.11116/0000-000C-BBAD-F

Abstract

Chlamydia trachomatis is the most prevalent sexually transmitted bacterial infection worldwide and the leading cause of preventable blindness. Reports have emerged of treatment failure, suggesting a need to develop new antibiotics to battle Chlamydia infection. One possible candidate for a new treatment is the protease inhibitor JO146, which is an effective anti-Chlamydia agent that targets the CtHtrA protein. CtHtrA is a lynchpin on the chlamydial cell surface due to its essential and multifunctional roles in the bacteria's stress response, replicative phase of development, virulence and outer-membrane protein assembly. This review summarizes the current understanding of CtHtrA function and presents a mechanistic model that highlights CtHtrA as an effective target for anti-Chlamydia drug development.