RRMdb: an evolutionary-oriented database of RNA recognition motif sequences

Nowacka, M; Boccaletto, P; Jankowska, A; Jarzynka, T; Bujnicki, JM; Dunin-Horkawicz, S

doi:10.1093/database/bay148

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RRMdb: an evolutionary-oriented database of RNA recognition motif sequences

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Nowacka, M., Boccaletto, P., Jankowska, A., Jarzynka, T., Bujnicki, J., & Dunin-Horkawicz, S. (2019). RRMdb: an evolutionary-oriented database of RNA recognition motif sequences. Database: The Journal of Biological Databases and Curation, 2019: bay148. doi:10.1093/database/bay148.

Cite as: https://hdl.handle.net/21.11116/0000-000C-BE9E-D

Abstract

RNA-recognition motif (RRM) is an RNA-interacting protein domain that plays an important role in the processes of RNA metabolism such as the splicing, editing, export, degradation, and regulation of translation. Here, we present the RNA-recognition motif database (RRMdb), which affords rapid identification and annotation of RRM domains in a given protein sequence. The RRMdb database is compiled from ~57 000 collected representative RRM domain sequences, classified into 415 families. Whenever possible, the families are associated with the available literature and structural data. Moreover, the RRM families are organized into a network of sequence similarities that allows for the assessment of the evolutionary relationships between them.