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Journal Article

The multifaceted mitochondrial OXA insertase


Rehling,  Peter
MPI-NAT Fellow Mitochondrial Biogenesis and Assembly of membrane Protein Complexes, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Homberg, B., Rehling, P., & Cruz-Zaragoza, L. D. (2023). The multifaceted mitochondrial OXA insertase. Trends in Cell Biology, in press. doi:10.1016/j.tcb.2023.02.001.

Cite as: https://hdl.handle.net/21.11116/0000-000C-D009-F
Most mitochondrial proteins are synthesized in the cytosol and transported into mitochondria by protein translocases. Yet, mitochondria contain their own genome and gene expression system, which generates proteins that are inserted in the inner membrane by the oxidase assembly (OXA) insertase. OXA contributes to targeting proteins from both genetic origins. Recent data provides insights into how OXA cooperates with the mitochondrial ribosome during synthesis of mitochondrial-encoded proteins. A picture of OXA emerges in which it coordinates insertion of OXPHOS core subunits and their assembly into protein complexes but also participates in the biogenesis of select imported proteins. These functions position the OXA as a multifunctional protein insertase that facilitates protein transport, assembly, and stability at the inner membrane.