Cortical synaptic architecture supports flexible sensory computations

Scholl, Benjamin; Fitzpatrick, David

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Cortical synaptic architecture supports flexible sensory computations

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Scholl, Benjamin
Max Planck Florida Institute for Neuroscience, Max Planck Society;

Fitzpatrick, David
Max Planck Florida Institute for Neuroscience, Max Planck Society;

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Citation

Scholl, B., & Fitzpatrick, D. (2020). Cortical synaptic architecture supports flexible sensory computations. Current Opinion in Neurobiology, 41-45. Retrieved from http://www.sciencedirect.com/science/article/pii/S0959438820300337.

Cite as: https://hdl.handle.net/21.11116/0000-000C-DF8F-9

Abstract

Establishing the fundamental principles that underlie the integration of excitatory and inhibitory presynaptic input populations is crucial to understanding how individual cortical neurons transform signals from peripheral receptors. Here we review recent studies using novel tools to examine the functional properties of excitatory synaptic inputs and the tuning of excitation and inhibition onto individual neurons. New evidence challenges existing synaptic connectivity rules and suggests a more complex functional synaptic architecture that supports a broad range of operations, enabling single neurons to encode multiple sensory features and flexibly shape their computations in the face of diverse sensory input.