IgSF11 homophilic adhesion proteins promote layer-specific synaptic assembly of 
the cortical interneuron subtype

Hayano, Yasufumi; Ishino, Yugo; Hyun, Jung Ho; Orozco, Carlos G.; Steinecke, André; Potts, Elizabeth; Oisi, Yasuhiro; Thomas, Connon I.; Guerrero-Given, Debbie; Kim, Eunjoon; Kwon, Hyung-Bae; Kamasawa, Naomi; Taniguchi, Hiroki

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IgSF11 homophilic adhesion proteins promote layer-specific synaptic assembly of the cortical interneuron subtype

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Hayano, Yasufumi
Max Planck Florida Institute for Neuroscience, Max Planck Society;

Ishino, Yugo
Max Planck Florida Institute for Neuroscience, Max Planck Society;

Hyun, Jung Ho
Max Planck Florida Institute for Neuroscience, Max Planck Society;

Orozco, Carlos G.
Max Planck Florida Institute for Neuroscience, Max Planck Society;

Steinecke, André
Max Planck Florida Institute for Neuroscience, Max Planck Society;

Potts, Elizabeth
Max Planck Florida Institute for Neuroscience, Max Planck Society;

Oisi, Yasuhiro
Max Planck Florida Institute for Neuroscience, Max Planck Society;

Thomas, Connon I.
Max Planck Florida Institute for Neuroscience, Max Planck Society;

Guerrero-Given, Debbie
Max Planck Florida Institute for Neuroscience, Max Planck Society;

Kim, Eunjoon
Max Planck Florida Institute for Neuroscience, Max Planck Society;

Kwon, Hyung-Bae
Max Planck Florida Institute for Neuroscience, Max Planck Society;

Kamasawa, Naomi
Max Planck Florida Institute for Neuroscience, Max Planck Society;

Taniguchi, Hiroki
Max Planck Florida Institute for Neuroscience, Max Planck Society;

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Citation

Hayano, Y., Ishino, Y., Hyun, J. H., Orozco, C. G., Steinecke, A., Potts, E., et al. (2021). IgSF11 homophilic adhesion proteins promote layer-specific synaptic assembly of the cortical interneuron subtype. Science Advances, (29). Retrieved from https://advances.sciencemag.org/content/7/29/eabf1600.

Cite as: https://hdl.handle.net/21.11116/0000-000C-DFD0-E

Abstract

The most prominent structural hallmark of the mammalian neocortical circuitry is the layer-based organization of specific cell types and synaptic inputs. Accordingly, cortical inhibitory interneurons (INs), which shape local network activity, exhibit subtype-specific laminar specificity of synaptic outputs. However, the underlying molecular mechanisms remain unknown. Here, we demonstrate that Immunoglobulin Superfamily member 11 (IgSF11) homophilic adhesion proteins are preferentially expressed in one of the most distinctive IN subtypes, namely, chandelier cells (ChCs) that specifically innervate axon initial segments of pyramidal neurons (PNs), and their synaptic laminar target. Loss-of-function experiments in either ChCs or postsynaptic cells revealed that IgSF11 is required for ChC synaptic development in the target layer. While overexpression of IgSF11 in ChCs enlarges ChC presynaptic boutons, expressing IgSF11 in nontarget layers induces ectopic ChC synapses. These findings provide evidence that synapse-promoting adhesion proteins, highly localized to synaptic partners, determine the layer-specific synaptic connectivity of the cortical IN subtype.
IgSF11 homophilic cell adhesion molecules regulate the synaptic laminar specificity of cortical chandelier cells.
IgSF11 homophilic cell adhesion molecules regulate the synaptic laminar specificity of cortical chandelier cells.