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Journal Article

When cleaning facilitates cluttering: genome editing in ciliates

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Seah,  BKB       
Research Group Ciliate Genomics and Molecular Biology, Max Planck Institute for Biology Tübingen, Max Planck Society;

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Swart,  EC       
Research Group Ciliate Genomics and Molecular Biology, Max Planck Institute for Biology Tübingen, Max Planck Society;

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Citation

Seah, B., & Swart, E. (2023). When cleaning facilitates cluttering: genome editing in ciliates. Trends in Genetics, 39(5), 344-346. doi:10.1016/j.tig.2023.02.016.


Cite as: https://hdl.handle.net/21.11116/0000-000C-E05D-F
Abstract
Many organisms remove DNA from their genomes during development. This has foremost been characterized as a means of defending genomes against mobile elements. However, genome editing actually hides such elements from purifying selection, with the survivors evolving approximately neutrally, 'cluttering' the germline genome, enabling it to enlarge over time.