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Connecting social behaviour and phenotypic plasticity through the nekl-4 kinase in Pristionchus pacificus nematodes

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Moreno,  E       
Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Lenuzzi,  M
Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Rödelsperger,  C       
Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society;
Evolutionary Genomics and Bioinformatics Group, Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Witte,  H       
Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Sommer,  R       
Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Citation

Moreno, E., Lenuzzi, M., Rödelsperger, C., Witte, H., & Sommer, R. (2018). Connecting social behaviour and phenotypic plasticity through the nekl-4 kinase in Pristionchus pacificus nematodes. Poster presented at EMBO Workshop: C. elegans development, cell biology and gene expression, Barcelona, Spain.


Cite as: https://hdl.handle.net/21.11116/0000-000C-EB65-A
Abstract
Nematodes respond to a multitude of environmental cues, which are integrated into the neural circuit through sensory neurons and produce two kinds of responses: adaptive behaviours and developmental decisions that influence morphological plastic traits. The beetle-associated nematode Pristionchus pacificus performs oxygen-induced social behaviours, similarly to Caenorhabditis elegans, which are regulated by sensory cilia in both species. Mutations affecting intraflagellar transport (IFT) components induce social behaviours in both C. elegans N2 and P. pacificus PS312 wild type animals. Contrary to C. elegans, P. pacificus shows phenotypic plasticity in the feeding structures, resulting in two distinct morphs adapted to feed on different food sources. Specifically, eurystomatous morphs have two movable teeth and are facultative predators on other nematodes, whereas stenostomatous morphs have only one tooth and feed exclusively on bacteria. Recently, we have discovered a mouth-form phenotype associated with mutations in some of the IFT components. We have studied further the combined regulation of social behaviours and mouth-form dimorphism by means of a suppressor screen performed on a klp-20;osm-3 double kinesin mutant. This experiment allowed us to identify the kinase nekl-4 as an important component of the signal transduction pathway that integrates environmental inputs into the neural circuit. Given the lack of information about the function of nekl- 4 in nematodes, we are currently performing a functional characterizing of nekl-4 in P. pacificus, by analysing its expression pattern and the epistatic interactions with previously described mouth-form regulatory genes. Besides, we are analysing the phosphoproteome of nekl-4 mutants in order to identify its interacting partners.