Habitual daily intake of a sweet and fatty snack modulates reward processing in 
humans

Edwin Thanarajah, Sharmili; DiFeliceantonio, Alexandra; Albus, Kerstin; Kuzmanovic, Bojana; Rigoux, Lionel; Iglesias, Sandra; Hanßen, Ruth; Schlamann, Marc; Cornely, Oliver Andreas; Brüning, Jens Claus; Tittgemeyer, Marc; Small, Dana M.

doi:10.1016/j.cmet.2023.02.015

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Habitual daily intake of a sweet and fatty snack modulates reward processing in humans

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Edwin Thanarajah, Sharmili
Translational Neurocircuitry, Research Groups, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society;

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DiFeliceantonio, Alexandra
Translational Neurocircuitry, Research Groups, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society;

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Kuzmanovic, Bojana
Translational Neurocircuitry, Research Groups, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society;

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Rigoux, Lionel
Translational Neurocircuitry, Research Groups, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society;

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Hanßen, Ruth
Tittgemeyer – Translational Neurocircuitry, Research Groups, Max Planck Institute for Metabolism Research, Max Planck Society;

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Brüning, Jens Claus
Brüning – Neuronal Control of Metabolism, Department Brüning, Max Planck Institute for Metabolism Research, Max Planck Society;

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Tittgemeyer, Marc
Tittgemeyer – Translational Neurocircuitry, Research Groups, Max Planck Institute for Metabolism Research, Max Planck Society;

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Small, Dana M.
Neuronal Control of Metabolism, Department Jens Brüning, Max Planck Institute for Metabolism Research, Managing Director: Jens Brüning, Max Planck Society;

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Citation

Edwin Thanarajah, S., DiFeliceantonio, A., Albus, K., Kuzmanovic, B., Rigoux, L., Iglesias, S., et al. (2023). Habitual daily intake of a sweet and fatty snack modulates reward processing in humans. Cell Metabolism, 35(4), 571-584.e6. doi:10.1016/j.cmet.2023.02.015.

Cite as: https://hdl.handle.net/21.11116/0000-000C-F59A-2

Abstract

Western diets rich in fat and sugar promote excess calorie intake and weight gain; however, the underlying mechanisms are unclear. Despite a well-documented association between obesity and altered brain dopamine function, it remains elusive whether these alterations are (1) pre-existing, increasing the individual susceptibility to weight gain, (2) secondary to obesity, or (3) directly attributable to repeated exposure to western diet. To close this gap, we performed a randomized, controlled study (NCT05574660) with normal-weight participants exposed to a high-fat/high-sugar snack or a low-fat/low-sugar snack for 8 weeks in addition to their regular diet. The high-fat/high-sugar intervention decreased the preference for low-fat food while increasing brain response to food and associative learning independent of food cues or reward. These alterations were independent of changes in body weight and metabolic parameters, indicating a direct effect of high-fat, high-sugar foods on neurobehavioral adaptations that may increase the risk for overeating and weight gain.