Help Privacy Policy Disclaimer
  Advanced SearchBrowse




Journal Article

Aggregation controlled by condensate rheology


Weber,  Christoph A.
Max Planck Institute for the Physics of Complex Systems, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
Supplementary Material (public)
There is no public supplementary material available

Pönisch, W., Michaels, T. C. T., & Weber, C. A. (2023). Aggregation controlled by condensate rheology. Biophysical Journal, 122(1), 197-214. doi:10.1016/j.bpj.2022.11.009.

Cite as: https://hdl.handle.net/21.11116/0000-000D-143B-B
Biomolecular condensates in living cells can exhibit a complex rheology, including viscoelastic and glassy behavior. This rheological behavior of condensates was suggested to regulate polymerization of cytoskeletal filaments and ag-gregation of amyloid fibrils. Here, we theoretically investigate how the rheological properties of condensates can control the for-mation of linear aggregates. To this end, we propose a kinetic theory for linear aggregation in coexisting phases, which accounts for the aggregate size distribution and the exchange of aggregates between inside and outside of condensates. The rheology of condensates is accounted in our model via aggregate mobilities that depend on aggregate size. We show that condensate rheology determines whether aggregates of all sizes or dominantly small aggregates are exchanged between condensate inside and outside on the timescale of aggregation. As a result, the ratio of aggregate numbers inside to outside of condensates differs significantly. Strikingly, we also find that weak variations in the rheological properties of condensates can lead to a switch-like change of the number of aggregates. These results suggest a possible physical mechanism for how living cells could control linear aggregation in a switch-like fashion through variations in condensate rheology.