A roadmap to establish a comprehensive platform for sustainable manufacturing 
of natural products in yeast.

Naseri, Gita

doi:10.1038/s41467-023-37627-1

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A roadmap to establish a comprehensive platform for sustainable manufacturing of natural products in yeast.

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Naseri, Gita
Max Planck Unit for the Science of Pathogens, Max Planck Society;

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Citation

Naseri, G. (2023). A roadmap to establish a comprehensive platform for sustainable manufacturing of natural products in yeast. Nat Commun, 14(1), 1916. doi:10.1038/s41467-023-37627-1.

Cite as: https://hdl.handle.net/21.11116/0000-000C-FD97-D

Abstract

Secondary natural products (NPs) are a rich source for drug discovery. However, the low abundance of NPs makes their extraction from nature inefficient, while chemical synthesis is challenging and unsustainable. Saccharomyces cerevisiae and Pichia pastoris are excellent manufacturing systems for the production of NPs. This Perspective discusses a comprehensive platform for sustainable production of NPs in the two yeasts through system-associated optimization at four levels: genetics, temporal controllers, productivity screening, and scalability. Additionally, it is pointed out critical metabolic building blocks in NP bioengineering can be identified through connecting multilevel data of the optimized system using deep learning.