Epigenome-wide meta-analysis of prenatal maternal stressful life events and 
newborn DNA methylation

Ruehlmann, Anna Kotsakis; Sammallahti, Sara; Hidalgo, Andrea P. Cortes; Bakulski, Kelly M.; Binder, Elisabeth B.; Campbell, Megan Loraine; Caramaschi, Doretta; Cecil, Charlotte A. M.; Colicino, Elena; Cruceanu, Cristiana; Czamara, Darina; Dieckmann, Linda; Dou, John; Felix, Janine F.; Frank, Josef; Haberg, Siri E.; Herberth, Gunda; Hoang, Thanh T.; Houtepen, Lotte C.; Huls, Anke; Koen, Nastassja; London, Stephanie J.; Magnus, Maria C.; Mancano, Giulia; Mulder, Rosa H.; Page, Christian M.; Raikkonen, Katri; Roeder, Stefan; Schmidt, Rebecca J.; Send, Tabea S.; Sharp, Gemma; Stein, Dan J.; Streit, Fabian; Tuhkanen, Johanna; Witt, Stephanie H.; Zar, Heather J.; Zenclussen, Ana C.; Zhang, Yining; Zillich, Lea; Wright, Rosalind; Lahti, Jari; Brunst, Kelly J.

doi:10.1038/s41380-023-02010-5

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学術論文

Epigenome-wide meta-analysis of prenatal maternal stressful life events and newborn DNA methylation

MPS-Authors

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Binder, Elisabeth B.
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;

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Cruceanu, Cristiana
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;

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Czamara, Darina
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;

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Dieckmann, Linda
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;
IMPRS Translational Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

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引用

Ruehlmann, A. K., Sammallahti, S., Hidalgo, A. P. C., Bakulski, K. M., Binder, E. B., Campbell, M. L., Caramaschi, D., Cecil, C. A. M., Colicino, E., Cruceanu, C., Czamara, D., Dieckmann, L., Dou, J., Felix, J. F., Frank, J., Haberg, S. E., Herberth, G., Hoang, T. T., Houtepen, L. C., Huls, A., Koen, N., London, S. J., Magnus, M. C., Mancano, G., Mulder, R. H., Page, C. M., Raikkonen, K., Roeder, S., Schmidt, R. J., Send, T. S., Sharp, G., Stein, D. J., Streit, F., Tuhkanen, J., Witt, S. H., Zar, H. J., Zenclussen, A. C., Zhang, Y., Zillich, L., Wright, R., Lahti, J., & Brunst, K. J. (2023). Epigenome-wide meta-analysis of prenatal maternal stressful life events and newborn DNA methylation. MOLECULAR PSYCHIATRY. doi:10.1038/s41380-023-02010-5.

引用: https://hdl.handle.net/21.11116/0000-000D-0743-0

要旨

Prenatal maternal stressful life events are associated with adverse neurodevelopmental outcomes in offspring. Biological mechanisms underlying these associations are largely unknown, but DNA methylation likely plays a role. This meta-analysis included twelve non-overlapping cohorts from ten independent longitudinal studies (N = 5,496) within the international Pregnancy and Childhood Epigenetics consortium to examine maternal stressful life events during pregnancy and DNA methylation in cord blood. Children whose mothers reported higher levels of cumulative maternal stressful life events during pregnancy exhibited differential methylation of cg26579032 in ALKBH3. Stressor-specific domains of conflict with family/friends, abuse (physical, sexual, and emotional), and death of a close friend/relative were also associated with differential methylation of CpGs in APTX, MyD88, and both UHRF1 and SDCCAG8, respectively; these genes are implicated in neurodegeneration, immune and cellular functions, regulation of global methylation levels, metabolism, and schizophrenia risk. Thus, differences in DNA methylation at these loci may provide novel insights into potential mechanisms of neurodevelopment in offspring.