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Journal Article

Associations between mental health, blood pressure and the development of hypertension

MPS-Authors
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Schaare,  Herma Lina       
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Otto Hahn Group Cognitive Neurogenetics, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Institute of Neuroscience and Medicine, Research Center Jülich, Germany;
Institute of Systems Neuroscience, University Hospital Düsseldorf, Germany;

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Blöchl,  Maria       
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Institute of Psychology, University of Leipzig, Germany;

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Kumral,  Deniz       
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Department of Psychology, Albert Ludwigs University Freiburg, Germany;
Department of Clinical Psychology and Psychotherapy, Albert Ludwigs University Freiburg, Germany;

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Uhlig,  Marie
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

Lemcke,  Lorenz
Methods and Development Group Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Valk,  Sofie L.       
Otto Hahn Group Cognitive Neurogenetics, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Institute of Neuroscience and Medicine, Research Center Jülich, Germany;
Institute of Systems Neuroscience, University Hospital Düsseldorf, Germany;

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Villringer,  Arno       
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
MindBrainBody Institute, Berlin School of Mind and Brain, Humboldt University Berlin, Germany;
Clinic for Cognitive Neurology, University of Leipzig, Germany;
Charité University Medicine Berlin, Germany;

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Schaare_2023.pdf
(Publisher version), 3MB

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Schaare_2023_Suppl.pdf
(Supplementary material), 2MB

Citation

Schaare, H. L., Blöchl, M., Kumral, D., Uhlig, M., Lemcke, L., Valk, S. L., et al. (2023). Associations between mental health, blood pressure and the development of hypertension. Nature Communications, 14: 1953. doi:10.1038/s41467-023-37579-6.


Cite as: https://hdl.handle.net/21.11116/0000-000D-05F5-9
Abstract
Multiple studies have reported a link between mental health and high blood pressure with mixed or even contradictory findings. Here, we resolve those contradictions and further dissect the cross-sectional and longitudinal relationship between mental health, systolic blood pressure, and hypertension using extensive psychological, medical and neuroimaging data from the UK Biobank. We show that higher systolic blood pressure is associated with fewer depressive symptoms, greater well-being, and lower emotion-related brain activity. Interestingly, impending hypertension is associated with poorer mental health years before HTN is diagnosed. In addition, a stronger baseline association between systolic blood pressure and better mental health was observed in individuals who develop hypertension until follow-up. Overall, our findings offer insights on the complex relationship between mental health, blood pressure, and hypertension, suggesting that—via baroreceptor mechanisms and reinforcement learning—the association of higher blood pressure with better mental health may ultimately contribute to the development of hypertension.