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Journal Article

Slow integrin-dependent migration organizes networks of tissue-resident mast cells

MPS-Authors

Kaltenbach,  Lukas
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Martzloff,  Paloma
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Bambach,  Sarah K
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Aizarani,  Nadim
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Mihlan,  Michael
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Gavrilov,  Alina
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Glaser,  Katharina M
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Stecher,  Manuel
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Lämmermann,  Tim
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

External Resource

https://www.nature.com/articles/s41590-023-01493-2
(Publisher version)

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Fulltext (public)

10.1038_s41590-023-01493-2.pdf
(Publisher version), 22MB

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Citation

Kaltenbach, L., Martzloff, P., Bambach, S. K., Aizarani, N., Mihlan, M., Gavrilov, A., et al. (2023). Slow integrin-dependent migration organizes networks of tissue-resident mast cells. Nature Immunology. doi:10.1038/s41590-023-01493-2.


Cite as: https://hdl.handle.net/21.11116/0000-000D-0DC3-9
Abstract
Immune cell locomotion is associated with amoeboid migration, a flexible mode of movement, which depends on rapid cycles of actin polymerization and actomyosin contraction1. Many immune cells do not necessarily require integrins, the major family of adhesion receptors in mammals, to move productively through three-dimensional tissue spaces2,3. Instead, they can use alternative strategies to transmit their actin-driven forces to the substrate, explaining their migratory adaptation to changing external environments4,5,6. However, whether these generalized concepts apply to all immune cells is unclear. Here, we show that the movement of mast cells (immune cells with important roles during allergy and anaphylaxis) differs fundamentally from the widely applied paradigm of interstitial immune cell migration. We identify a crucial role for integrin-dependent adhesion in controlling mast cell movement and localization to anatomical niches rich in KIT ligand, the major mast cell growth and survival factor. Our findings show that substrate-dependent haptokinesis is an important mechanism for the tissue organization of resident immune cells.