HSCs: slow me down with PLAG1

Zhang, Yu Wei; Cabezas-Wallscheid, Nina

doi:10.1182/blood.2022017069

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HSCs: slow me down with PLAG1

MPS-Authors

Zhang, Yu Wei
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Cabezas-Wallscheid, Nina
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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https://ashpublications.org/blood/article/140/9/935/486391/HSCs-slow-me-down-with-PLAG1
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10.1182_blood.2022017069.pdf
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Citation

Zhang, Y. W., & Cabezas-Wallscheid, N. (2022). HSCs: slow me down with PLAG1. Blood, 140, 935-936. doi:10.1182/blood.2022017069.

Cite as: https://hdl.handle.net/21.11116/0000-000D-10CD-A

Abstract

In this issue of Blood, Keyvani Chahi et al¹ have described the transcription factor PLAG1 as a positive regulator of human cord blood (CB) hematopoietic stem cell (HSC) dormancy and self-renewal by repressing the expression of translational machinery that is customarily activated in response to ex vivo cultivation stress.