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Journal Article

Parental mutations influence wild-type offspring via transcriptional adaptation

MPS-Authors
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Jiang,  Zhen
Developmental Genetics, Max Planck Institute for Heart and Lung Research, Max Planck Society;

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El-Brolosy,  Mohamed A.
Developmental Genetics, Max Planck Institute for Heart and Lung Research, Max Planck Society;

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Serobyan,  Vahan
Developmental Genetics, Max Planck Institute for Heart and Lung Research, Max Planck Society;
Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Welker,  Jordan M.
Developmental Genetics, Max Planck Institute for Heart and Lung Research, Max Planck Society;

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Retzer,  Nicholas
Developmental Genetics, Max Planck Institute for Heart and Lung Research, Max Planck Society;

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Dooley,  Christopher M.
Developmental Genetics, Max Planck Institute for Heart and Lung Research, Max Planck Society;
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

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Jakutis,  Gabrielius
Developmental Genetics, Max Planck Institute for Heart and Lung Research, Max Planck Society;

Juan,  Thomas
Developmental Genetics, Max Planck Institute for Heart and Lung Research, Max Planck Society;

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Fukuda,  Nana
Developmental Genetics, Max Planck Institute for Heart and Lung Research, Max Planck Society;

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Maischein,  Hans-Martin
Developmental Genetics, Max Planck Institute for Heart and Lung Research, Max Planck Society;
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;
Research Group Colour Pattern Formation, Max Planck Institute for Developmental Biology, Max Planck Society;

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Stainier,  Didier Y. R.
Developmental Genetics, Max Planck Institute for Heart and Lung Research, Max Planck Society;

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Citation

Jiang, Z., El-Brolosy, M. A., Serobyan, V., Welker, J. M., Retzer, N., Dooley, C. M., et al. (2022). Parental mutations influence wild-type offspring via transcriptional adaptation. SCIENCE ADVANCES, 8(47): eabj2029. doi:10.1126/sciadv.abj2029.


Cite as: https://hdl.handle.net/21.11116/0000-000D-1C0B-9
Abstract
Transgenerational epigenetic inheritance (TEI) is mostly discussed in the context of physiological or environmental factors. Here, we show intergenerational and transgenerational inheritance of transcriptional adaptation (TA), a process whereby mutant messenger RNA (mRNA) degradation affects gene expression, in nematodes and zebrafish. Wild-type offspring of animals heterozygous for mRNA-destabilizing alleles display increased expression of adapting genes. Notably, offspring of animals heterozygous for nontranscribing alleles do not display this response. Germline-specific mutations are sufficient to induce TA in wild-type offspring, indicating that, at least for some genes, mutations in somatic tissues are not necessary for this process. Microinjecting total RNA from germ cells of TA-displaying heterozygous zebrafish can trigger TA in wild-type embryos and in their progeny, suggesting a model whereby mutant mRNAs in the germline trigger a TA response that can be epigenetically inherited. In sum, this previously unidentified mode of TEI reveals a means by which parental mutations can modulate the offspring's transcriptome.