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Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease

MPS-Authors
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Schäffner,  Erik
Neurogenetics, Max Planck Institute of Experimental Medicine, Max Planck Society;

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Edgar,  Julia M.
Neurogenetics, Max Planck Institute of Experimental Medicine, Max Planck Society;

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Berghoff,  Stefan A.
Neurogenetics, Max Planck Institute of Experimental Medicine, Max Planck Society;

/persons/resource/persons182306

Möbius,  W.
Neurogenetics, Max Planck Institute of Experimental Medicine, Max Planck Society;

/persons/resource/persons182152

Fledrich,  Robert
Molecular and translational neurology, Neurogenetics, Max Planck Institute of Experimental Medicine, Max Planck Society;

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Stassart,  Ruth M.
Neurogenetics, Max Planck Institute of Experimental Medicine, Max Planck Society;

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Nave,  Klaus-Armin
Neurogenetics, Max Planck Institute of Experimental Medicine, Max Planck Society;

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Citation

Schäffner, E., Edgar, J. M., Lehning, M., Strauß, J., Bosch-Queralt, M., Wieghofer, P., et al. (2021). Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease. bioRxiv. doi:10.1101/2021.11.11.468223.


Cite as: https://hdl.handle.net/21.11116/0000-000D-1D4E-D
Abstract
Axonal degeneration determines the clinical outcome of multiple sclerosis (MS), and is thought to result from exposure of denuded axons to immune-mediated damage. We challenge this view after finding in MS and its mouse models that myelin itself increases the risk of axons to degenerate under inflammatory conditions. We propose a model for demyelinating diseases in which for axons that remain myelinated, and thus shielded from the extracellular milieu, dependence from oligodendroglial support turns fatal in an autoimmune disease environment.