Myelin insulation as a risk factor for axonal degeneration in autoimmune 
demyelinating disease

Schäffner, Erik; Edgar, Julia M.; Lehning, M.; Strauß, J.; Bosch-Queralt, M.; Wieghofer, P.; Berghoff, Stefan A.; Krueger, M.; Morawski, M.; Reinert, T.; Möbius, W.; Barrantes-Freer, A.; Prinz, M.; Reich, D.S.; Flügel, A.; Stadelmann, C.; Fledrich, Robert; Stassart, Ruth M.; Nave, Klaus-Armin

doi:10.1101/2021.11.11.468223

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Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease

MPS-Authors

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Schäffner, Erik
Neurogenetics, Max Planck Institute of Experimental Medicine, Max Planck Society;

/persons/resource/persons182137

Edgar, Julia M.
Neurogenetics, Max Planck Institute of Experimental Medicine, Max Planck Society;

/persons/resource/persons202532

Berghoff, Stefan A.
Neurogenetics, Max Planck Institute of Experimental Medicine, Max Planck Society;

/persons/resource/persons182306

Möbius, W.
Neurogenetics, Max Planck Institute of Experimental Medicine, Max Planck Society;

/persons/resource/persons182152

Fledrich, Robert
Molecular and translational neurology, Neurogenetics, Max Planck Institute of Experimental Medicine, Max Planck Society;

/persons/resource/persons182427

Stassart, Ruth M.
Neurogenetics, Max Planck Institute of Experimental Medicine, Max Planck Society;

/persons/resource/persons182320

Nave, Klaus-Armin
Neurogenetics, Max Planck Institute of Experimental Medicine, Max Planck Society;

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2021.11.11.468223v1.full.pdf
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引用

Schäffner, E., Edgar, J. M., Lehning, M., Strauß, J., Bosch-Queralt, M., Wieghofer, P., Berghoff, S. A., Krueger, M., Morawski, M., Reinert, T., Möbius, W., Barrantes-Freer, A., Prinz, M., Reich, D., Flügel, A., Stadelmann, C., Fledrich, R., Stassart, R. M., & Nave, K.-A. (2021). Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease. bioRxiv. doi:10.1101/2021.11.11.468223.

引用: https://hdl.handle.net/21.11116/0000-000D-1D4E-D

要旨

Axonal degeneration determines the clinical outcome of multiple sclerosis (MS), and is thought to result from exposure of denuded axons to immune-mediated damage. We challenge this view after finding in MS and its mouse models that myelin itself increases the risk of axons to degenerate under inflammatory conditions. We propose a model for demyelinating diseases in which for axons that remain myelinated, and thus shielded from the extracellular milieu, dependence from oligodendroglial support turns fatal in an autoimmune disease environment.