Epidermal growth factor does not cross the blood-brain barrier

Nave, K.-A.; Probstmeier, Rainer; Schachner, Melitta

doi:10.1007/BF00217193

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Epidermal growth factor does not cross the blood-brain barrier

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Nave, K.-A.
Neurogenetics, Max Planck Institute of Experimental Medicine, Max Planck Society;

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Nave, K.-A., Probstmeier, R., & Schachner, M. (1985). Epidermal growth factor does not cross the blood-brain barrier. Cell and Tissue Research, 241, 453-457. doi:10.1007/BF00217193.

Cite as: https://hdl.handle.net/21.11116/0000-000D-2AB3-A

Abstract

To measure the passage of epidermal growth factor (EGF) through the blood-brain barrier (BBB) 125Ilabeled EGF was injected intravenously into adult rats. The distribution of ¹²⁵I-EGF in the blood and cerebrospinal fluid (CSF) was determined over a time period of several hours. Between 2 to 6 h a stable distribution of intact ¹²⁵IEGF in CSF was measured to be approximately 1/500 of the blood-borne EGF, an equilibrium value below those obtained by other investigators for BBB-impermeable compounds, such as inulin and bovine serum albumin. Our data indicate that ¹²⁵I-EGF, although clearly detectable in the CSF, does not cross the BBB at a higher rate or in higher quantities than would be expected from its molecular size.